Study: Genetic Risk Variant Linked to Astrocytes Increases Risk of MS – APhA submits compounding comments to FDA. – (866) 348-2889.
A genetic risk variant, rs7665090G, located near NFKB1, on astrocytes enhances the accessibility of the central nervous system (CNS) to peripheral immune cells, escalating the risk of autoimmune inflammation and multiple sclerosis (MS), according to the results of a recent study.
One recent finding suggested that changes in immune enhancers such as lymphocytes may disrupt innate and adaptive immune pathways; however, investigators were still unsure whether they affected CNS function and thus increased MS risk. In this study, rs7665090G was used to determine whether dysregulation in astrocyte function will affect MS risk.